Diclofenac suppositories 12.5 mg are indicated for the relief of mild to moderate pain and inflammation, contraindicated in patients with a history of hypersensitivity to diclofenac or other NSAIDs, may cause side effects such as gastrointestinal discomfort, headache, or dizziness, and can interact with anticoagulants, other NSAIDs, and certain antihypertensive medications.